Z-D-GLUTAMIC ACID GAMMA-METHYL ESTER
Z-D-GLU(OME)-OH
CAS: 27025-24-7
Molecular Formula: C14H17NO6
Z-D-GLUTAMIC ACID GAMMA-METHYL ESTER - Names and Identifiers
Z-D-GLUTAMIC ACID GAMMA-METHYL ESTER - Physico-chemical Properties
| Molecular Formula | C14H17NO6 |
| Molar Mass | 295.29 |
| Density | 1.272±0.06 g/cm3(Predicted) |
| Melting Point | 65-70 °C |
| Boling Point | 510.6±50.0 °C(Predicted) |
| pKa | 3.80±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
Z-D-GLUTAMIC ACID GAMMA-METHYL ESTER - Introduction
Z-D-GLU(OME)-OH (Z-D-GLU) is a compound that can be used to synthesize biologically active peptides and proteins. It is a white solid, soluble in organic solvents such as dimethyl sulfoxide (DMSO) and chloroform.
Z-D-GLU(OME)-OH is commonly used as a protecting group in peptide synthesis. Its main purpose is to protect the amino function of glutamic acid to prevent accidental side reactions in chemical reactions. When the synthesis needs to introduce glutamic acid into the compound, it can be protected using Z-D-GLU(OME)-OH, and the protecting group is removed after other reactions are completed.
Z-D-GLU(OME)-OH can be prepared by the following steps:
1. In the presence of carbonate, add N-tert-butoxicocaporone (Cbz-Cl) to acetone.
2. Glutamate is added to generate Z-D-GLU(OME)-OH.
Safety information, the presence of Z-D-GLU(OME)-OH may be toxic to humans. During use and storage, avoid inhalation of its dust or solution, and do not contact with skin and eyes. Necessary safety measures should be taken during operation, such as wearing protective glasses, gloves and protective clothing. In case of accidental contact or inhalation, seek medical attention immediately. In addition, the compound should be used and stored in a well-ventilated area.
Z-D-GLU(OME)-OH is commonly used as a protecting group in peptide synthesis. Its main purpose is to protect the amino function of glutamic acid to prevent accidental side reactions in chemical reactions. When the synthesis needs to introduce glutamic acid into the compound, it can be protected using Z-D-GLU(OME)-OH, and the protecting group is removed after other reactions are completed.
Z-D-GLU(OME)-OH can be prepared by the following steps:
1. In the presence of carbonate, add N-tert-butoxicocaporone (Cbz-Cl) to acetone.
2. Glutamate is added to generate Z-D-GLU(OME)-OH.
Safety information, the presence of Z-D-GLU(OME)-OH may be toxic to humans. During use and storage, avoid inhalation of its dust or solution, and do not contact with skin and eyes. Necessary safety measures should be taken during operation, such as wearing protective glasses, gloves and protective clothing. In case of accidental contact or inhalation, seek medical attention immediately. In addition, the compound should be used and stored in a well-ventilated area.
Last Update：2024-04-09 20:52:54
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